Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2

Binding of initiator methionyl-tRNA to ribosomes is catalyzed in prokaryotes by initiation factor (IF) IF2 and in eukaryotes by eIF2. The discovery of both IF2 and eIF2 homologs in yeast and archaea suggested that these microbes possess an evolutionarily intermediate protein synthesis apparatus. We...

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Bibliographic Details
Main Authors: Lee, Joon H., Choi, Sang Ki, Roll-Mecak, Antonina, Burley, Stephen K., Dever, Thomas E.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC16334/
https://ncbi.nlm.nih.gov/pubmed/10200264
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