Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2

Binding of initiator methionyl-tRNA to ribosomes is catalyzed in prokaryotes by initiation factor (IF) IF2 and in eukaryotes by eIF2. The discovery of both IF2 and eIF2 homologs in yeast and archaea suggested that these microbes possess an evolutionarily intermediate protein synthesis apparatus. We...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lee, Joon H., Choi, Sang Ki, Roll-Mecak, Antonina, Burley, Stephen K., Dever, Thomas E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16334/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10200264/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.8.4342
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