Kill kinetics and regrowth patterns of Pseudomonas aeruginosa exposed to concentration-time profiles of tobramycin simulating in vivo infusion and bolus dosing.

Pseudomonas aeruginosa ATCC 27853 was exposed to tobramycin concentration-time profiles modelling in vivo bolus and infusion dosing. Dependence of bactericidal and bacteriostatic activity on the initial profile of peak concentration (bolus effect > infusion) and area under the antibiotic concentrati...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Wood, P J, Ioannides-Demos, L L, Bastone, E B, Spicer, W J, McLean, A J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163321/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8723496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.5.1321
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