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A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein α-subunit with impaired receptor-mediated activation because of elevated GTPase activity

It has been reported that substitution of Arg(258), a residue within the GTPase domain of the heterotrimeric guanine nucleotide binding protein (G protein) α-subunit (α(s)), to alanine (α(s)-R258A) results in decreased activation by receptor or aluminum fluoride (AlF(4)(−)) and increased basal GDP r...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Warner, Dennis R., Weinstein, Lee S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16321/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10200251/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.8.4268
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