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A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein α-subunit with impaired receptor-mediated activation because of elevated GTPase activity
It has been reported that substitution of Arg(258), a residue within the GTPase domain of the heterotrimeric guanine nucleotide binding protein (G protein) α-subunit (α(s)), to alanine (α(s)-R258A) results in decreased activation by receptor or aluminum fluoride (AlF(4)(−)) and increased basal GDP r...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The National Academy of Sciences
1999
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC16321/ https://ncbi.nlm.nih.gov/pubmed/10200251 |
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