Predictors of effect of ampicillin-sulbactam against TEM-1 beta-lactamase-producing Escherichia coli in an in vitro dynamic model: enzyme activity versus MIC.

The clinical outcome in patients treated with ampicillin-sulbactam may not always be predictable by disc susceptibility testing or with the MIC as determined with a constant level (4 micrograms/ml) of the beta-lactamase inhibitor (MIC1). The enzyme activities (EA) and the MICs estimated at a constan...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Firsov, A A, Savarino, D, Ruble, M, Gilbert, D, Manzano, B, Medeiros, A A, Zinner, S H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8851602/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.3.734
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