Activity of trovafloxacin (CP-99,219) against Legionella isolates: in vitro activity, intracellular accumulation and killing in macrophages, and pharmacokinetics and treatment of guinea pigs with L. pneumophila pneumonia.

The activity of trovafloxacin against 22 clinical Legionella isolates was determined by broth microdilution susceptibility testing. The trovafloxacin concentration required to inhibit 90% of strains tested was < or = 0.004 micrograms/ml, in contrast to 0.032 micrograms/ml for ofloxacin. In guinea pi...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Edelstein, P H, Edelstein, M A, Ren, J, Polzer, R, Gladue, R P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163108/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834872/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.314
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