Activity of trovafloxacin (CP-99,219) against Legionella isolates: in vitro activity, intracellular accumulation and killing in macrophages, and pharmacokinetics and treatment of guinea pigs with L. pneumophila pneumonia.

The activity of trovafloxacin against 22 clinical Legionella isolates was determined by broth microdilution susceptibility testing. The trovafloxacin concentration required to inhibit 90% of strains tested was < or = 0.004 micrograms/ml, in contrast to 0.032 micrograms/ml for ofloxacin. In guinea pi...

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Detaylı Bibliyografya

Yayımlandı:	Antimicrob Agents Chemother
Asıl Yazarlar:	Edelstein, P H, Edelstein, M A, Ren, J, Polzer, R, Gladue, R P
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Microbiology (ASM) 1996
Konular:	Research Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163108/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834872/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.314
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