Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease.

AG1343 ([3S-(3R*,4aR*,8aR*,2'S*,3'S*)]-2-[2' hydroxy-3'-phenylthiomethyl-4'-aza-5'-oxo-5'-(2''-methyl-3''-hydro xy-phenyl) pentyl]-decahydroiso-quinoline-3-N-t-butylcarboxamide methanesulfonic acid) is a selective, nonpeptidic inhibitor of human immunodeficiency virus (HIV) protease (Ki = 2 nM) that...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Patick, A K, Mo, H, Markowitz, M, Appelt, K, Wu, B, Musick, L, Kalish, V, Kaldor, S, Reich, S, Ho, D, Webber, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163104/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834868/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.292
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