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Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.

PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovu...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Rusconi, S, Moonis, M, Merrill, D P, Pallai, P V, Neidhardt, E A, Singh, S K, Willis, K J, Osburne, M S, Profy, A T, Jenson, J C, Hirsch, M S
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163090/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8787913/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.1.234
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