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Transfection Activity of Binary Mixtures of Cationic O-Substituted Phosphatidylcholine Derivatives: The Hydrophobic Core Strongly Modulates Physical Properties and DNA Delivery Efficacy

A combination of two cationic lipid derivatives having the same headgroup but tails of different chain lengths has been shown to have considerably different transfection activity than do the separate molecules. Such findings point to the importance of investigating the hydrophobic portions of cation...

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Bibliografiske detaljer
Main Authors: Wang, Li, Koynova, Rumiana, Parikh, Harsh, MacDonald, Robert C.
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1630455/
https://ncbi.nlm.nih.gov/pubmed/16935955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.092700
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