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An intracellular lamellar–nonlamellar phase transition rationalizes the superior performance of some cationic lipid transfection agents
Two cationic phospholipid derivatives with asymmetric hydrocarbon chains were synthesized: ethyl esters of oleoyldecanoyl-ethylphosphatidylcholine (C18:1/C10-EPC) and stearoyldecanoyl-ethylphosphatidylcholine (C18:0/C10-EPC). The former was 50 times more effective as a DNA transfection agent (human...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1599970/ https://ncbi.nlm.nih.gov/pubmed/16983097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603085103 |
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