An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes

The heterohexameric origin recognition complex (ORC) acts as a scaffold for the G(1) phase assembly of pre-replicative complexes (pre-RC). Only the Orc1-5 subunits appear to be required for origin binding in budding yeast, yet Orc6 is an essential protein for cell proliferation. Imaging of Orc6-YFP...

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Hlavní autoři: Semple, Jeffrey W, Da-Silva, Lance F, Jervis, Eric J, Ah-Kee, Jennifer, Al-Attar, Hyder, Kummer, Lutz, Heikkila, John J, Pasero, Philippe, Duncker, Bernard P
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1630405/
https://ncbi.nlm.nih.gov/pubmed/17053779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601391
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