Inhibition of episomal hepatitis B virus DNA in vitro by 2,4-diamino-7- (2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-pyrrolo[2,3-d]pyrimidine.

The nucleoside analog 2,4-diamino-7-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)pyrrolo[2,3-d]pyrimidine (T70080) and several related compounds were evaluated for anti-hepatitis B virus (HBV) activity by using cultured 2.2.15 cells. T70080 reduced episomal viral replication in these cells by 50% at a...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Ojwang, J O, Bhattacharya, B K, Marshall, H B, Korba, B E, Revankar, G R, Rando, R F
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1995
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162987/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8585748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.11.2570
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