Population differences in ganciclovir clearance as determined by nonlinear mixed-effects modelling.

We examined the pharmacokinetics of ganciclovir in different populations of cytomegalovirus (CMV)-infected patients through the use of nonlinear mixed-effects modelling. As expected, patient weight and estimated creatinine clearance were shown to be important covariates in the serum ganciclovir clea...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Yuen, G J, Drusano, G L, Fletcher, C, Capparelli, E, Connor, J D, Lalezari, J P, Drew, L, Follansbee, S, Busch, D, Jacobson, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162943/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8619596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.10.2350
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