Pharmacokinetics of MDL 63,246, a new semisynthetic glycopeptide antibiotic, in the rat.

Following intravenous administration in the rat, the concentration of MDL 63,246 in plasma was high and long-lasting. Concentrations fell with an apparent three-exponential decay. MDL 63,246 was distributed in a high volume and was cleared quite slowly. The pharmacokinetics of MDL 63,246 in the rat...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Borgonovi, M, Cavenaghi, L A, Borghi, A, Galimberti, M, Kaltofen, P, Merati, R, Coutant, J E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162909/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8619562/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.10.2176
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