Mechanism of action of antimycobacterial activity of the new benzoxazinorifamycin KRM-1648.

The mechanism of antimicrobial activity of KRM-1648 (KRM), a new rifamycin derivative with potent antimycobacterial activity, was studied. Both KRM and rifampin (RMP) inhibited RNA polymerases from Escherichia coli and Mycobacterium avium at low concentrations: the 50% inhibitory concentrations (IC5...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Fujii, K, Saito, H, Tomioka, H, Mae, T, Hosoe, K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162768/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7492091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.7.1489
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