Point mutation in the pribnow box, the molecular basis of beta-lactamase overproduction in Klebsiella oxytoca.

Klebsiella oxytoca mutants resistant to a variety of beta-lactams were obtained in vitro on aztreonam. Constitutive beta-lactamase production was much higher in the mutants than in the susceptible strains (75-fold). The only difference observed in these mutants compared with the susceptible strains...

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Библиографические подробности
Главные авторы: Fournier, B, Lu, C Y, Lagrange, P H, Krishnamoorthy, R, Philippon, A
Формат: Artigo
Язык:Inglês
Опубликовано: 1995
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC162743/
https://ncbi.nlm.nih.gov/pubmed/7574532
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