Vaccination with Tat toxoid attenuates disease in simian/HIV-challenged macaques

The Tat protein is essential for HIV type 1 (HIV-1) replication and may be an important virulence factor in vivo. We studied the role of Tat in viral pathogenesis by immunizing rhesus macaques with chemically inactivated Tat toxoid and challenging these animals by intrarectal inoculation with the si...

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Detalhes bibliográficos
Main Authors: Pauza, C. David, Trivedi, Parul, Wallace, Marianne, Ruckwardt, Tracy J., Le Buanec, Hélene, Lu, Wei, Bizzini, Bernard, Burny, Arséne, Zagury, Daniel, Gallo, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16271/
https://ncbi.nlm.nih.gov/pubmed/10725402
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