Vaccination with Tat toxoid attenuates disease in simian/HIV-challenged macaques

The Tat protein is essential for HIV type 1 (HIV-1) replication and may be an important virulence factor in vivo. We studied the role of Tat in viral pathogenesis by immunizing rhesus macaques with chemically inactivated Tat toxoid and challenging these animals by intrarectal inoculation with the si...

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Главные авторы: Pauza, C. David, Trivedi, Parul, Wallace, Marianne, Ruckwardt, Tracy J., Le Buanec, Hélene, Lu, Wei, Bizzini, Bernard, Burny, Arséne, Zagury, Daniel, Gallo, Robert C.
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2000
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC16271/
https://ncbi.nlm.nih.gov/pubmed/10725402
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