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Phosphatidylinositol 3-kinase p85 alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population
AIMS/HYPOTHESIS: Phosphatidylinositol 3-kinase (PI3K) couples the leptin and insulin signalling pathways via IRS-1 and IRS-2. Hence, defective activation of PI3K could be a novel mechanism of peripheral leptin or insulin resistance. We investigated association of tagging SNPs (tSNPs) in the PI3K p85...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1626353/ https://ncbi.nlm.nih.gov/pubmed/17016694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-006-0388-z |
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