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Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

Basal cell carcinoma is the most prevalent cancer in the western world, showing a rapid increase in incidence. Activation of the Sonic hedgehog/Patched (PTCH) signaling pathway because of PTCH1 inactivation is a key event in sporadic and familial basal cell carcinoma development in humans and is ass...

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Detalhes bibliográficos
Main Authors: Nilsson, Mats, Undèn, Anne Birgitte, Krause, Darren, Malmqwist, Ulrica, Raza, Karima, Zaphiropoulos, Peter G., Toftgård, Rune
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16258/
https://ncbi.nlm.nih.gov/pubmed/10725363
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