Abnormal passive chloride absorption in cystic fibrosis jejunum functionally opposes the classic chloride secretory defect

Due to genetic defects in apical membrane chloride channels, the cystic fibrosis (CF) intestine does not secrete chloride normally. Depressed chloride secretion leaves CF intestinal absorptive processes unopposed, which results in net fluid hyperabsorption, dehydration of intestinal contents, and a...

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Autori principali: Russo, Michael A., Högenauer, Christoph, Coates, Stephen W., Santa Ana, Carol A., Porter, Jack L., Rosenblatt, Randall L., Emmett, Michael, Fordtran, John S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2003
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC162286/
https://ncbi.nlm.nih.gov/pubmed/12840066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317667
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