Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice

The homeobox transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic neurons in a cell-autonomous and gene-dose-dependent manner. Because of this requirement, the cells die by apoptosis when all four alleles of the Engrailed genes are genetically...

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Autors principals: Sgadò, Paola, Albéri, Lavinia, Gherbassi, Daniel, Galasso, Sherri L., Ramakers, Geert M. J., Alavian, Kambiz N., Smidt, Marten P., Dyck, Richard H., Simon, Horst H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1622807/
https://ncbi.nlm.nih.gov/pubmed/17015829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602116103
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