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Elevated P75(NTR )expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression
BACKGROUND: The homeodomain transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic (mesDA) neurons in a cell-autonomous and gene-dose-dependent manner. Homozygote mutant mice, deficient of both genes (En1-/-;En2-/-), die at birth and exhibit a l...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667502/ https://ncbi.nlm.nih.gov/pubmed/19291307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1749-8104-4-11 |
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