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Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
The homeobox transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic neurons in a cell-autonomous and gene-dose-dependent manner. Because of this requirement, the cells die by apoptosis when all four alleles of the Engrailed genes are genetically...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1622807/ https://ncbi.nlm.nih.gov/pubmed/17015829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602116103 |
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