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Single-chain Tet transregulators

We demonstrate here that the Tet repressor (TetR), a dimeric allosterical regulatory protein, can be converted to a fully functional monomer when connected by a 29 amino acid linker. TetR-based transregulators are widely used to regulate gene expression in eukaryotes. They can be fused to form singl...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Krueger, Christel, Berens, Christian, Schmidt, Andreas, Schnappinger, Dirk, Hillen, Wolfgang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162254/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12799431/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg421
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