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Signal transduction by a nondissociable heterotrimeric yeast G protein

Many signal transduction pathways involve heterotrimeric G proteins. The accepted model for activation of heterotrimeric G proteins states that the protein dissociates to the free G(α) (GTP)-bound subunit and free G(βγ) dimer. On GTP hydrolysis, G(α) (GDP) then reassociates with G(βγ) [Gilman, A. G....

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Autores principales: Klein, Shoshana, Reuveni, Hadas, Levitzki, Alexander
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC16219/
https://ncbi.nlm.nih.gov/pubmed/10725354
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