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The metabolism of clomethiazole in gerbils and the neuroprotective and sedative activity of the metabolites
1. A single dose of clomethiazole (600 μmol kg(−1) i.p.) has previously been shown to be neuroprotective in the gerbil model of global ischaemia. 2. In gerbils, clomethiazole (600 μmol kg(−1)) injection produced a rapid appearance (peak within 5 min) of drug in plasma and brain and similar clearance...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1621131/ https://ncbi.nlm.nih.gov/pubmed/10694207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703042 |
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