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The metabolism of clomethiazole in gerbils and the neuroprotective and sedative activity of the metabolites

1. A single dose of clomethiazole (600 μmol kg(−1) i.p.) has previously been shown to be neuroprotective in the gerbil model of global ischaemia. 2. In gerbils, clomethiazole (600 μmol kg(−1)) injection produced a rapid appearance (peak within 5 min) of drug in plasma and brain and similar clearance...

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Hlavní autoři: Green, A R, Murray, T K, Misra, A, Snape, M F, Jones, J A, Cross, A J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1621131/
https://ncbi.nlm.nih.gov/pubmed/10694207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703042
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