Protonation of the β-lactam nitrogen is the trigger event in the catalytic action of class A β-lactamases
The pH dependence of the pK(a) values of all ionizable groups and of the electrostatic potential at grid points corresponding to catalytically important atoms in the active site of TEM-1 β-lactamase has been calculated by a mean-field approach for reaction intermediates modeled on the basis of energ...
保存先:
| 出版年: | Proc Natl Acad Sci U S A |
|---|---|
| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2000
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16209/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10716727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.060027897 |
| タグ: |
タグなし, このレコードへの初めてのタグを付けませんか!
|