Protonation of the β-lactam nitrogen is the trigger event in the catalytic action of class A β-lactamases
The pH dependence of the pK(a) values of all ionizable groups and of the electrostatic potential at grid points corresponding to catalytically important atoms in the active site of TEM-1 β-lactamase has been calculated by a mean-field approach for reaction intermediates modeled on the basis of energ...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16209/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10716727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.060027897 |
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