Combined Contributions of Streptolysin O and Streptolysin S to Virulence of Serotype M5 Streptococcus pyogenes Strain Manfredo

Streptolysin O (SLO) and streptolysin S (SLS) are potent cytolytic toxins produced by almost all clinical isolates of group A streptococci (GAS). Allele-replacement mutagenesis was used to construct nonpolar (in-frame) deletion mutations in the slo and sagB genes of the serotype M5 GAS strain Manfre...

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Bibliographic Details
Main Authors: Fontaine, Michael C., Lee, Jeong Jin, Kehoe, Michael A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC162000/
https://ncbi.nlm.nih.gov/pubmed/12819070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.7.3857-3865.2003
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