HuR binding to cytoplasmic mRNA is perturbed by heat shock

AU-rich elements (AREs) located in the 3′ untranslated region target the mRNAs encoding many protooncoproteins, cytokines, and lymphokines for rapid degradation. HuR, a ubiquitously expressed member of the embryonic lethal abnormal vision (ELAV) family of RNA-binding proteins, binds ARE sequences an...

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Hauptverfasser: Gallouzi, Imed-Eddine, Brennan, Christopher M., Stenberg, Myrna G., Swanson, Maurice S., Eversole, Ashley, Maizels, Nancy, Steitz, Joan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16194/
https://ncbi.nlm.nih.gov/pubmed/10737787
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