Induction of Inflammatory Mediators and Microglial Activation in Mice Transgenic for Mutant Human P301S Tau Protein

Mice transgenic for human P301S tau protein exhibit many characteristics of the human tauopathies, including the formation of abundant filaments made of hyperphosphorylated tau protein and neurodegeneration leading to nerve cell loss. At 5 months of age, the pathological changes are most marked in b...

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Bibliografiske detaljer
Main Authors: Bellucci, Arianna, Westwood, Andrew J., Ingram, Esther, Casamenti, Fiorella, Goedert, Michel, Spillantini, Maria Grazia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2004
Fag:
Original Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618683/
https://ncbi.nlm.nih.gov/pubmed/15509534
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