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Crystal structure of the functional domain of the splicing factor Prp18

The splicing factor Prp18 is required for the second step of pre-mRNA splicing. We have isolated and determined the crystal structure of a large fragment of the Saccharomyces cerevisiae Prp18 that lacks the N-terminal 79 amino acids. This fragment, called Prp18Δ79, is fully active in yeast splicing...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Jiang, Jianzhong, Horowitz, David S., Xu, Rui-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2000
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16185/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10737784/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.7.3022
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