In Vitro Selection and Characterization of Bacillus anthracis Mutants with High-Level Resistance to Ciprofloxacin

Mutants of attenuated Bacillus anthracis with high-level ciprofloxacin resistance were isolated using a three-step in vitro selection. Ciprofloxacin MICs were 0.5 μg/ml for first-step mutants, which had one of two gyrA quinolone resistance-determining region (QRDR) mutations. Ciprofloxacin MICs were...

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Bibliographic Details
Main Authors: Price, Lance B., Vogler, Amy, Pearson, Talima, Busch, Joseph D., Schupp, James M., Keim, Paul
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC161847/
https://ncbi.nlm.nih.gov/pubmed/12821500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.7.2362-2365.2003
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