Farnesol Biosynthesis in Candida albicans: Cellular Response to Sterol Inhibition by Zaragozic Acid B

The dimorphic fungus Candida albicans produces farnesol as a quorum-sensing molecule that regulates cellular morphology. The biosynthetic origin of farnesol has been resolved by treating these cells with zaragozic acid B, a potent inhibitor of squalene synthase in the sterol biosynthetic pathway. Tr...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Hornby, Jacob M., Kebaara, Bessie W., Nickerson, Kenneth W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161837/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12821501/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.7.2366-2369.2003
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