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Farnesol Biosynthesis in Candida albicans: Cellular Response to Sterol Inhibition by Zaragozic Acid B

The dimorphic fungus Candida albicans produces farnesol as a quorum-sensing molecule that regulates cellular morphology. The biosynthetic origin of farnesol has been resolved by treating these cells with zaragozic acid B, a potent inhibitor of squalene synthase in the sterol biosynthetic pathway. Tr...

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Autori principali: Hornby, Jacob M., Kebaara, Bessie W., Nickerson, Kenneth W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC161837/
https://ncbi.nlm.nih.gov/pubmed/12821501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.7.2366-2369.2003
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