Role of RNA Structure and RNA Binding Activity of Foot-and-Mouth Disease Virus 3C Protein in VPg Uridylylation and Virus Replication

The uridylylation of the VPg peptide primer is the first stage in the replication of picornavirus RNA. This process can be achieved in vitro using purified components, including 3B (VPg) with the RNA dependent RNA polymerase (3D(pol)), the precursor 3CD, and an RNA template containing the cre/bus. W...

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Detalhes bibliográficos
Main Authors: Nayak, Arabinda, Goodfellow, Ian G., Woolaway, Kathryn E., Birtley, James, Curry, Stephen, Belsham, Graham J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617274/
https://ncbi.nlm.nih.gov/pubmed/16973591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00561-06
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