Kaposi's Sarcoma-Associated Herpesvirus Lytic Switch Protein Stimulates DNA Binding of RBP-Jk/CSL To Activate the Notch Pathway

Kaposi's sarcoma-associated herpesvirus (KSHV) lytic switch protein, Rta, is a ligand-independent inducer of the Notch signal transduction pathway, and KSHV cannot reactivate from latency in cells null for the Notch target protein RBP-Jk. Here we show that Rta promotes DNA binding of RBP-Jk, a...

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Bibliographic Details
Main Authors: Carroll, Kyla Driscoll, Bu, Wei, Palmeri, Diana, Spadavecchia, Sophia, Lynch, Stephen J., Marras, Salvatore A. E., Tyagi, Sanjay, Lukac, David M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617261/
https://ncbi.nlm.nih.gov/pubmed/16973574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00746-06
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