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Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice

The c-MYC protooncogene is overexpressed in the most malignant primary brain tumor, glioblastoma multiforme (GBM), and has been correlated with the undifferentiated character of several cell types. However, the role of Myc activity in the generation of GBMs is not known. In this report, we show that...

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Detalhes bibliográficos
Main Authors: Lassman, Andrew B., Dai, Chengkai, Fuller, Gregory N., Vickers, Andrew J., Holland, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615889/
https://ncbi.nlm.nih.gov/pubmed/17047730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/s1740925x04000249
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