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Fading of 5-HT(4) receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium
Inotropic responses to 5-hydroxytryptamine (5-HT) in human and porcine atrium can fade, suggesting 5-HT(4) receptor desensitization. De Maeyer et al., however, show in this issue that inhibition of phosphodiesterases with isobutyl-methyl-xanthine prevents fading of 5-HT(4) receptor-mediated response...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1615854/ https://ncbi.nlm.nih.gov/pubmed/16331292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706501 |
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