Advanced Glycation End Products Induce Tubular Epithelial-Myofibroblast Transition through the RAGE-ERK1/2 MAP Kinase Signaling Pathway

Advanced glycation end products (AGEs) have been shown to play a role in tubular epithelial-myofibroblast transdifferentiation (TEMT) in diabetic nephropathy, but the intracellular signaling pathway remains unknown. We report here that AGEs signal through the receptor for AGEs (RAGE) to induce TEMT,...

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Bibliographic Details
Main Authors: Li, Jin H., Wang, Wansheng, Huang, Xiao R., Oldfield, Matthew, Schmidt, Ann M., Cooper, Mark E., Lan, Hui Y.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615341/
https://ncbi.nlm.nih.gov/pubmed/15039226
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