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Multiple Structural and Functional Abnormalities in the P450 Aromatase Expressing Transgenic Male Mice Are Ameliorated by a P450 Aromatase Inhibitor

The present study was undertaken to analyze the effect of a P450 aromatase inhibitor (finrozole) on 4-month-old transgenic mice expressing human P450 aromatase (P450arom) under the human ubiquitin C promoter (AROM+). AROM+ mice present several dysfunctions, such as adrenal and pituitary hyperplasia,...

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Main Authors: Li, Xiangdong, Strauss, Leena, Mäkelä, Sari, Streng, Tomi, Huhtaniemi, Ilpo, Santti, Risto, Poutanen, Matti
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1614717/
https://ncbi.nlm.nih.gov/pubmed/14982857
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