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Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

Both insulin and IGF-1 have been implicated in control of retinal endothelial cell growth, neovascularization, and diabetic retinopathy. To precisely define the role of insulin and IGF-1 signaling in endothelium in these processes, we have used the oxygen-induced retinopathy model to study mice with...

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Bibliografiske detaljer
Main Authors: Kondo, Tatsuya, Vicent, David, Suzuma, Kiyoshi, Yanagisawa, Masashi, King, George L., Holzenberger, Martin, Kahn, C. Ronald
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC161423/
https://ncbi.nlm.nih.gov/pubmed/12813019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317455
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