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A rapid genome-scale response of the transcriptional oscillator to perturbation reveals a period-doubling path to phenotypic change

Perturbation of the gated-synchrony system in yeast with phenelzine, an antidepressant drug used in the treatment of affective disorders in humans, leads to a rapid lengthening in the period of the genome-wide transcriptional oscillation. The effect is a concerted, genome-scale change in expression...

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Detalhes bibliográficos
Main Authors: Li, Caroline M., Klevecz, Robert R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1613231/
https://ncbi.nlm.nih.gov/pubmed/17043222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604860103
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