Potent Antiviral Synergy between Monoclonal Antibody and Small-Molecule CCR5 Inhibitors of Human Immunodeficiency Virus Type 1

The chemokine receptor CCR5 provides a portal of entry for human immunodeficiency virus type 1 (HIV-1) into susceptible CD4(+) cells. Both monoclonal antibody (MAb) and small-molecule CCR5 inhibitors have entered human clinical testing, but little is known regarding their potential interactions. We...

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Bibliografiska uppgifter
Huvudupphovsmän: Murga, Jose D., Franti, Michael, Pevear, Daniel C., Maddon, Paul J., Olson, William C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2006
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1610098/
https://ncbi.nlm.nih.gov/pubmed/17005807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00699-06
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