Enhanced Membrane Disruption and Antibiotic Action against Pathogenic Bacteria by Designed Histidine-Rich Peptides at Acidic pH

The histidine-rich amphipathic cationic peptide LAH4 has antibiotic and DNA delivery capabilities. Here, we explore the interaction of peptides from this family with model membranes as monitored by solid-state (2)H nuclear magnetic resonance and their antibiotic activities against a range of bacteri...

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Detalhes bibliográficos
Main Authors: Mason, A. James, Gasnier, Claire, Kichler, Antoine, Prévost, Gilles, Aunis, Dominique, Metz-Boutigue, Marie-Hélène, Bechinger, Burkhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1610059/
https://ncbi.nlm.nih.gov/pubmed/17005809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00490-06
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