Short G-rich oligonucleotides as a potential therapeutic for Huntington's Disease

BACKGROUND: Huntington's Disease (HD) is an inherited autosomal dominant genetic disorder in which neuronal tissue degenerates. The pathogenesis of the disease appears to center on the development of protein aggregates that arise initially from the misfolding of the mutant HD protein. Mutant hu...

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Hauptverfasser: Skogen, Michael, Roth, Jennifer, Yerkes, Sarah, Parekh-Olmedo, Hetal, Kmiec, Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1609172/
https://ncbi.nlm.nih.gov/pubmed/17014717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-7-65
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