Glypican-1 Is Frequently Overexpressed in Human Gliomas and Enhances FGF-2 Signaling in Glioma Cells

Signaling by fibroblast growth factor 2 (FGF-2), an autocrine stimulator of glioma growth, is regulated by heparan sulfate proteoglycans (HSPGs) via a ternary complex with FGF-2 and the FGF receptor (FGFR). To characterize glioma growth signaling, we examined whether altered HSPGs contribute to loss...

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Autores principales: Su, Gui, Meyer, Kristy, Nandini, Chilkunda D., Qiao, Dianhua, Salamat, Shahriar, Friedl, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2006
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606624/
https://ncbi.nlm.nih.gov/pubmed/16723715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050800
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